Design and Analysis of Studies Based on Hierarchical Composite Endpoints: Insights from the DARE-19 Trial
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Abstract
HCEs are flexible endpoints that can be adapted for use in different therapeutic areas, with win odds as the analysis method. DARE-19 is an example of a COVID-19 trial with an HCE as one of the primary endpoints for estimating a clinically interpretable treatment effect in the COVID-19 setting.
- Design and Analysis of Studies Based on Hierarchical Composite Endpoints: Insights from the DARE-19 Trial was published in Therapeutic Innovation & Regulatory Science (2022), 56(5): 785–794.
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