Design and Analysis of Studies Based on Hierarchical Composite Endpoints: Insights from the DARE-19 Trial

Image credit: Springer Nature Switzerland AG


HCEs are flexible endpoints that can be adapted for use in different therapeutic areas, with win odds as the analysis method. DARE-19 is an example of a COVID-19 trial with an HCE as one of the primary endpoints for estimating a clinically interpretable treatment effect in the COVID-19 setting.

Samvel B. Gasparyan
Samvel B. Gasparyan

Biostatistician in cardiovascular trials.